Frankfurt am Main is the largest city in the German state of Hessen and the fifth-largest city in Germany. The city is at the centre of the larger Frankfurt Rhine-Main Metropolitan Region and is Germany's second-largest metropolitan region. Frankfurt is a centre for commerce, culture, education, tourism and web traffic. Messe Frankfurt is one of the world's largest trade fairs at 578,000 square metres and ten exhibition halls. Major trade fairs include the Frankfurt Motor Show, the world's largest motor show, and the Frankfurt Book Fair, the world's largest book fair.Frankfurt is home to many cultural and educational institutions, including the Johann Wolfgang Goethe University and Frankfurt University of Applied Sciences, many museums (e.g. Städel, Naturmuseum Senckenberg, Schirn Kunsthalle Frankfurt, Goethe House) and two major botanical gardens: the Palmengarten, which is Germany's largest, and the Botanical Garden of Goethe University.